Vitamin D & COVID-19 Immunity

By | July 16, 2020

The role of vitamin D in preventing viral infections, including COVID-19, is gaining attention as more studies are released.  In this video, Dr. Seheult of https://www.medcram.com discusses a recent vitamin D review article published in the peer-reviewed journal Nutrients which has compelling implications for COVID-19 and overall vascular and endothelial health.

Studies mentioned in the video:

Immunologic Effects of Vitamin D on Human Health and Disease, July 9
https://www.mdpi.com/2072-6643/12/7/2097

Vitamin D status and risk of all-cause and cause-specific mortality in a large cohort: results from the UK Biobank
https://academic.oup.com/jcem/article-abstract/doi/10.1210/clinem/dgaa432/5867168

Besides these studies, an older one in american hospitals had shown that Vitamin D Insufficiency is Prevalent in Severe COVID-19.
85% of patients in ICUs had vit.D insufficiency (and 100% of the ones <75 years old).
https://www.medrxiv.org/content/10.1101/2020.04.24.20075838v1
“We determined the frequency of VDI among COVID-19 patients to evaluate the likelihood of a VDI-COVID-19 relationship. Results: Twenty COVID-19 patients with serum 25OHD levels were identified; 65.0% required ICU admission.The VDI prevalence in ICU patients was 84.6%, vs. 57.1% in floor patients. Strikingly, 100% of ICU patients less than 75 years old had VDI. Coagulopathy was present in 62.5% of ICU COVID-19 patients, and 92.3% were lymphocytopenic. Conclusions: VDI is highly prevalent in severe COVID-19 patients. VDI and severe COVID-19 share numerous associations including hypertension, obesity, male sex, advanced age, concentration in northern climates, coagulopathy, and immune dysfunction. Thus, we suggest that prospective, randomized controlled studies of VDI in COVID-19 patients are warranted.”